Department of Chemical and Biomolecular Engineering
PhD & MS(MEBCS): Singapore-MIT Alliance, NUS 2008 & 2004
ME & BE (Chem.Eng.) Tsinghua University, China 2002 & 2000
Blk E5, 4 Engineering Drive 4, #03-18, Singapore 117576
Tel: (65) 6516 1067 Fax: (65) 6779 1936
Metal nanomaterials of different sizes, shapes, and structures are finding increasing acceptance in biological applications. Metal nanomaterials can be interfaced with biological materials to form a new class of designer organic-inorganic hybrids (BioNanoMetals) which can be used to enable the green synthesis of metal nanomaterials and the safe use of nanometals in biomedical applications. Our research group is interested in investigating the basic design principles for functional BioNanoMetals and addressing fundamental issues on the interactions between the biological systems and metal nanomaterials. There are two major parts of our research.
1. Green Chemistry for Shape- and Size-Controlled Synthesis of Nanometals
Recent pursuit of the sustainable nanotechnology has attracted increasing emphasis on the development of cost effective and environmental benign procedures (“green chemistry”) in nanomaterials synthesis. This entails necessarily the use of an environmentally acceptable solvent system, an eco-friendly reducing agent, and a non-hazardous capping agent for the stabilization of the nanomaterials formed. The use of biology as a synthetic tool for metal nanomaterials satisfies all these selection criteria. An additional advantage of this method is the as-synthesized nanomaterials are decorated with biological species, which help improve the biocompatibility of the final products for biomedical applications.
2. Explore Biomedical Applications of Biogenerated Nanometals
The unusual optical properties of small metal nanomaterials, their size-dependent electrochemistry, their high chemical stability, and their highly biocompatible surfaces (biomolecules) have made them the model system of choice for exploring a wide range of biomedical applications including diagnostics (e.g. bioimaging and biosensing) and therapeutics (e.g. drug delivery and photothermal ablation).
Xie, J.; Zheng, Y.; Ying, J. Y. "Protein-Directed Synthesis of Highly Fluorescent Gold Nanoclusters”, Journal of the American Chemical Society, 2009, 131, 888-889.
Xie, J.; Zheng, Y.; Ying, J. Y. "Highly Selective and Ultrasensitive Detection of Hg2+ Based on Fluorescence Quenching of Au Nanoclusters by Hg2+···Au+ Interactions”, Chemical Communications, 2009, in press.
Zhang, Q.; Xie, J.; Liang, J.; Lee, J. Y. "Synthesis of Monodisperse Ag-Au Alloy Nanoparticles with Independently Tunable Morphology, Composition, Size and Surface Chemistry and Their 3-D Superlattices”, Advanced Functional Materials, 2009, 19, 1387-1398.
Xie, J.; Zhang, Q.; Lee, J. Y.; Wang, D. I. C. "The Synthesis of SERS-Active Gold Nanoflower Tags for In Vivo Applications”, ACS Nano, 2008, 2, 2473-2480.
Xie, J.; Lee, J. Y.; Wang, D. I. C.; Ting, Y. P. "Silver Nanoplates: From Biological to Biomimetic Synthesis”, ACS Nano, 2007, 1, 429-439.
Xie, J.; Lee, J. Y.; Wang, D. I. C.; Ting, Y. P. "Identification of Active Biomolecules in the High-Yield Synthesis of Single-Crystalline Gold Nanoplates in Algal Solutions”, Small, 2007, 3, 672-682.